Oxygen/Ozone Treatment Reduces Surgical Adhesions in Rats
Author Information
Author(s): Clara Di Filippo, Annalisa Capuano, Barbara Rinaldi, Margherita Luongo, Biagio Lettieri, Francesco Rossi, Michele D'Amico
Primary Institution: 2nd University of Naples
Hypothesis
Can an oxygen/ozone mixture reduce the formation of postsurgical peritoneal adhesions?
Conclusion
The study found that treatment with an oxygen/ozone mixture significantly reduced the formation of postsurgical peritoneal adhesions in rats.
Supporting Evidence
- Rats treated with oxygen/ozone had lower scores for adhesion formation compared to those treated with oxygen.
- The levels of ubiquitin and 20S proteasome were significantly reduced in the oxygen/ozone group.
- The study suggests that the ubiquitin-proteasome system is involved in adhesion formation.
Takeaway
This study shows that giving rats a mix of oxygen and ozone before surgery helps prevent sticky tissues that can form after operations.
Methodology
The study involved two groups of male Sprague-Dawley rats, one treated with oxygen and the other with an oxygen/ozone mixture, followed by surgical procedures to induce adhesions.
Participant Demographics
Male Sprague-Dawley rats, aged 4-6 months and weighing approximately 250g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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