Comparing Tumor Markers in Bladder Cancer
Author Information
Author(s): Abdulamir Ahmed S, Hafidh Rand R, Kadhim Haider S, Abubakar Fatimah
Primary Institution: University Putra Malaysia
Hypothesis
The study aims to elucidate the molecular pathways and clinicopathological criteria in schistosomal versus non-schistosomal bladder tumors.
Conclusion
The study found distinct molecular profiles in schistosomal and non-schistosomal bladder tumors, which could inform targeted cancer therapies.
Supporting Evidence
- SBT was associated with high grade invasive squamous cell carcinoma while NSBT was associated with lower grade less invasive transitional cell carcinoma.
- The expression of p53, bcl-2, c-myc, and EGFR was higher in SBT than in NSBT.
- Both SC and NSC showed higher levels of p53, bcl-2, ki-67, and EGFR than in the control group.
Takeaway
This study looked at different types of bladder cancer and found that they behave differently, which can help doctors choose the best treatment.
Methodology
The study used immunohistochemistry to analyze tumor markers in bladder cancer patients and compared results across different groups.
Potential Biases
Potential bias in patient selection and retrospective analysis of medical records.
Limitations
The study was limited to patients from specific geographical regions and may not be generalizable.
Participant Demographics
The study included 84 bladder cancer patients (63 men and 21 women) aged 38-72 years, with a predominance of schistosomal infections in younger males.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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