Study of Drug Resistant Mycobacterium tuberculosis in New Delhi
Author Information
Author(s): Stavrum Ruth, Myneedu Vithal Prasad, Arora Virendra K., Ahmed Niyaz, Grewal Harleen M. S.
Primary Institution: The Gade Institute, University of Bergen, Norway
Hypothesis
What is the genetic diversity and drug resistance profile of Mycobacterium tuberculosis isolates in New Delhi?
Conclusion
The study found a high frequency of drug-resistant mutations in Mycobacterium tuberculosis isolates from New Delhi, particularly in the CAS1_DELHI sub-lineage.
Supporting Evidence
- 46.2% of isolates belonged to the CAS1_DELHI sub-lineage.
- 15.4% of isolates had mutations conferring resistance to pyrazinamide.
- 56% of new tuberculosis patients had mutations in either the katG or rpoB genes.
Takeaway
Researchers looked at bacteria that cause tuberculosis in New Delhi and found many of them are resistant to medicines, which makes treating the disease harder.
Methodology
The study analyzed 68 Mycobacterium tuberculosis isolates using spoligotyping, MIRU-VNTR, and SNP analysis.
Potential Biases
Potential bias due to the small sample size and the specific location of the study.
Limitations
The study was limited to a single hospital in an urban setting, which may not represent the broader population.
Participant Demographics
48% of the patients were male, with a mean age of 30.6 years, and 84.6% were under 45 years old.
Statistical Information
P-Value
0.045
Confidence Interval
[1.11, 8.70]
Statistical Significance
p=0.045
Digital Object Identifier (DOI)
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