Nanoparticles Overcoming Drug Resistance in Cancer Treatment
Author Information
Author(s): Li Rutian, Xie Li, Zhu Zhenshu, Liu Qin, Hu Yong, Jiang Xiqun, Yu Lixia, Qian Xiaoping, Guo Wanhua, Ding Yitao, Liu Baorui
Primary Institution: The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University
Hypothesis
Can copolymeric nanoparticles reverse pH-induced physiological drug resistance (PIPDR) in cancer cells?
Conclusion
Copolymeric nanoparticles can effectively reverse PIPDR, enhancing the efficacy of weakly basic anticancer drugs.
Supporting Evidence
- The cytotoxicity of free Tetrandrine decreased significantly at lower pH levels.
- Tetrandrine-loaded nanoparticles maintained their effectiveness regardless of pH changes.
- In vivo studies showed that Tetrandrine nanoparticles had fewer side effects compared to free Tetrandrine.
- PET-CT imaging indicated reduced tumor metabolism with Tetrandrine nanoparticles.
- Nanoparticles entered cancer cells via endocytosis, avoiding drug protonation outside the cells.
Takeaway
Scientists found a way to help cancer drugs work better by using tiny particles that deliver the medicine directly into cancer cells, even when the environment around the cells is not friendly.
Methodology
The study compared the effectiveness of free Tetrandrine and Tetrandrine-loaded nanoparticles at different pH levels using in vitro assays and in vivo tumor models.
Potential Biases
Potential bias in the selection of drug formulations and animal models used.
Limitations
The study primarily focused on one type of drug and may not generalize to all anticancer agents.
Participant Demographics
Male ICR mice were used for in vivo experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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