Antidepressants and Hippocampal Progenitor Cells
Author Information
Author(s): Ko Hyoung-Gon, Lee Sung Joong, Son Hyeon, Kaang Bong-Kiun
Primary Institution: Seoul National University
Hypothesis
Antidepressants may act on astrocytes, inducing neurogenesis of hippocampal neural progenitor cells (NPCs).
Conclusion
Astrocytes increase the proliferation of hippocampal NPCs, but this is not directly involved in the antidepressant-induced proliferation of NPCs.
Supporting Evidence
- Antidepressants have been shown to induce the expression of GDNF mRNA.
- Naïve astrocytes increased the number of proliferating NPCs compared to control.
- Desipramine or fluoxetine treatment did not further increase NPC proliferation.
Takeaway
The study looked at how antidepressants affect brain cells called astrocytes and their ability to help other brain cells grow, but found that antidepressants don't help in this process.
Methodology
Used two co-culture systems to measure the proliferation of NPCs treated with antidepressant-treated astrocytes.
Limitations
The study may not account for different responses to antidepressants based on mouse strains or the timing of BrdU treatment.
Participant Demographics
Postnatal day 1 or 2 C57BL6/J mice were used for the experiments.
Statistical Information
P-Value
p > 0.05
Statistical Significance
p > 0.05
Digital Object Identifier (DOI)
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