Prognostic Factors in Advanced Epithelial Ovarian Cancer
Author Information
Author(s): S. Marsoni, V. Torri, M.G. Valsecchi, C. Belloni, U. Bianchi, G. Bolis, C. Bonazzi, N. Colombo, A. Epis, G. Favalli, A. Gambino, F. Landoni, R. Maggi, S. Pecorelli, S. Presti, L. Vassena, F. Zanaboni, C. Mangioni
Primary Institution: Istituto di Ricerche Farmacologiche Mario Negri
Hypothesis
What factors can predict survival in patients with advanced epithelial ovarian cancer?
Conclusion
The study found that residual tumor size, age, FIGO stage, and cell type are independent determinants of survival in advanced ovarian cancer patients.
Supporting Evidence
- The overall 3-year survival in this series of patients is twice that reported historically.
- Residual tumor size, age, FIGO stage, and cell type were all independent determinants of survival.
- 5-year survival rates ranged from 7 to 62% based on different prognostic groups.
Takeaway
Doctors can use certain factors to help predict how long patients with advanced ovarian cancer might live, but these factors don't always help in choosing the best treatment.
Methodology
The study analyzed data from 914 patients enrolled in four randomized trials using a proportional hazard regression model.
Potential Biases
There may be selection bias due to the characteristics of the treated groups and the types of treatments administered over time.
Limitations
The study's conclusions may be limited by the historical nature of the data and the potential biases in treatment assignment.
Participant Demographics
Patients were primarily women with advanced epithelial ovarian cancer, FIGO stage III and IV.
Statistical Information
Confidence Interval
95% CL 18.7-25.4
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website