Protein evolution of ANTP and PRD homeobox genes
2008
Protein evolution of ANTP and PRD homeobox genes
Sample size: 200
publication
Evidence: moderate
Author Information
Author(s): Nuno A Fonseca, Christina P Vieira, Peter W Holland, Jorge Vieira
Primary Institution: Instituto de Biologia Molecular e Celular (IBMC); University of Porto
Hypothesis
What are the main amino acid changes that occurred early in the evolution of homeobox genes?
Conclusion
The reported protein features will facilitate the robust classification of homeobox genes from newly sequenced bilaterian genomes.
Supporting Evidence
- The study identifies amino acid patterns that can distinguish between different homeobox gene classes.
- Phylogenetic analysis was used to classify homeobox genes into classes and subclasses.
- Key amino acid changes were found to be important for the evolution of homeobox genes.
Takeaway
This study helps scientists understand how certain genes have changed over time, which can help classify them better.
Methodology
The study used a hand-curated dataset and various software tools to identify amino acid patterns in homeobox genes.
Limitations
Findings must be cautiously applied to non-bilaterian genomes.
Digital Object Identifier (DOI)
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