Idiopathic Membranous Nephropathy in Children: Study Results
Author Information
Author(s): Chen Ashton, Frank Rachel, Vento Suzanne, Crosby Virginia, Chandra Manju, Gauthier Bernard, Valderrama Elsa, Trachtman Howard
Primary Institution: Schneider Children's Hospital of North Shore-Long Island Jewish Health System
Hypothesis
What is the presentation, response to therapy, and long-term outcome of pediatric patients with idiopathic membranous nephropathy?
Conclusion
Idiopathic membranous nephropathy is rare in children, and about 50% of patients may experience progressive kidney disease over time.
Supporting Evidence
- The study identified 13 cases of IMN out of 460 renal biopsies.
- At the last follow-up, 54% of patients were hypertensive.
- Approximately 50% of patients may have evidence of progressive kidney disease.
Takeaway
This study looked at kids with a rare kidney disease and found that many of them might have problems with their kidneys later on.
Methodology
A retrospective chart review of pediatric patients with biopsy-proven IMN from 1988 to 2005.
Potential Biases
Potential bias due to the retrospective nature of the study and lack of standardized treatment protocols.
Limitations
The small sample size limits the ability to generalize findings.
Participant Demographics
Mean age 9.6 years, 6 males and 7 females, with 8 White, 2 Black, and 3 Hispanic.
Statistical Information
P-Value
p>0.15
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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