Usefulness and safety of sodium hyaluronate for colorectal endoscopic resection
Author Information
Author(s): Hirasaki Shoji, Kozu Takahiro, Yamamoto Hironori, Sano Yasushi, Yahagi Naohisa, Oyama Tsuneo, Shimoda Tadakazu, Sugano Kentaro, Tajiri Hisao, Takekoshi Takao, Saito Daizo
Hypothesis
Can 0.4% sodium hyaluronate solution improve the outcomes of endoscopic resection for colorectal mucosal neoplasms?
Conclusion
0.4% sodium hyaluronate solution effectively lifts colorectal lesions during endoscopic resection, reducing complications compared to normal saline.
Supporting Evidence
- The usefulness rate of 0.4% sodium hyaluronate was 82.5%.
- 75% of patients experienced steep mucosal lesion-lifting.
- Only 10% of patients had intraoperative complications.
- The average time for mucosal resection was 6.7 minutes.
- 87.5% of patients found the mucosal resection easy.
Takeaway
This study shows that a special solution helps lift and remove growths in the colon safely during a procedure, making it easier for doctors.
Methodology
A prospective multi-center open-label study involving 41 patients with colorectal neoplastic lesions who underwent endoscopic resection using 0.4% sodium hyaluronate.
Potential Biases
Potential bias due to the single-arm design and the expertise of the endoscopists involved.
Limitations
The study had a modest sample size and was conducted by highly skilled endoscopists, which may not reflect general practice.
Participant Demographics
{"age":{"median":64,"range":"45-80"},"sex":{"male":27,"female":13}}
Statistical Information
P-Value
p<0.05
Confidence Interval
67.2–92.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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