FMO-4 Slows Aging Downstream of mTOR and DR Through ER to Mitochondria Calcium Signaling
2024
FMO-4 Slows Aging Through Calcium Signaling
publication
Author Information
Author(s): Tuckowski Angela, Beydoun Safa, Kitto Elizabeth, Bhat Ajay, Howington Marshall, Sridhar Aditya, Bhandari Mira, Chambers Kelly, Leiser Scott
Primary Institution: University of Michigan
Hypothesis
Modified calcium signaling is crucial for ER and mitochondrial homeostasis.
Conclusion
FMO-4 plays a significant role in promoting longevity and metabolism through its interaction with calcium signaling.
Supporting Evidence
- FMO-4 is required for dietary restriction and mTOR-mediated longevity.
- FMO-4 interacts with calcium signaling to promote healthy aging.
- FMO family enzymes are regulators of longevity across species.
Takeaway
This study shows that a specific enzyme, FMO-4, helps organisms live longer and healthier by managing calcium signals in their cells.
Digital Object Identifier (DOI)
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