Actin in Herpesvirus Infection
2011
Actin's Role in Herpesvirus Infection
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Kari L. Roberts, Joel D. Baines
Primary Institution: Department of Microbiology and Immunology, Cornell University
Hypothesis
Herpesviruses exploit actin and actin-associated myosin motors for viral entry, transport, and egress.
Conclusion
Actin plays a critical role in the lifecycle of herpesviruses, influencing their entry, replication, and egress from host cells.
Supporting Evidence
- Herpesviruses utilize host actin during infection.
- Actin dynamics are required for the entry of HSV-1 in certain cell types.
- Actin filaments form within the nucleus during herpesvirus infections.
- US3 kinase plays a role in actin stress fiber disassembly during infection.
Takeaway
Actin is like a helper that viruses use to get into cells and spread. It helps them move around inside the cell and get out to infect more cells.
Methodology
This is a review article summarizing various studies on the role of actin in herpesvirus infections.
Limitations
The review does not provide new experimental data and relies on existing literature.
Digital Object Identifier (DOI)
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