Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways
2008
Erect Wing and Synaptic Growth in Drosophila
Sample size: 21
publication
Evidence: high
Author Information
Author(s): Haussmann Irmgard U, White Kalpana, Soller Matthias
Primary Institution: School of Biosciences, University of Birmingham
Hypothesis
How does the Erect Wing gene regulate synaptic growth through multiple signaling pathways?
Conclusion
The Erect Wing gene restricts synaptic growth by integrating various cellular signaling pathways into a regulatory network.
Supporting Evidence
- EWG acts primarily through increasing mRNA levels of genes involved in transcriptional and post-transcriptional regulation.
- EWG genetically interacts with Wingless and Notch signaling pathways.
- Loss of EWG function leads to increased synaptic bouton numbers at neuromuscular junctions.
Takeaway
The Erect Wing gene helps control how much synapses grow in fruit flies by managing signals from different pathways.
Methodology
Functional genomics approach using clonal analysis in Drosophila to study synaptic growth at neuromuscular junctions.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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