HTLV-1 and Innate Immunity
2011
HTLV-1 and Innate Immunity
publication
Evidence: moderate
Author Information
Author(s): Chloé Journo, Renaud Mahieux
Primary Institution: INSERM-U758 Human Virology, Ecole Normale Supérieure de Lyon
Hypothesis
Does HTLV-1 infect cells that participate in the innate immune response in vivo?
Conclusion
HTLV-1 alters innate immune cell functions, impacting the immune response and treatment efficacy.
Supporting Evidence
- HTLV-1 infects T lymphocytes and alters type-I interferon function.
- IFN-α/AZT treatment can lead to complete remission in ATLL patients.
- HTLV-1 infection impairs the ability of innate immune cells to produce IFN-α.
Takeaway
HTLV-1 is a virus that can change how our immune system works, making it harder for the body to fight infections.
Methodology
The review discusses the interplay between HTLV-1 and innate immunity, focusing on the effects of the viral Tax protein on immune responses.
Limitations
The review is based on existing literature and may not cover all aspects of HTLV-1's interaction with the immune system.
Digital Object Identifier (DOI)
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