Bifidobacterium Strains and Their Effects on Immune Responses
Author Information
Author(s): López Patricia, González-Rodríguez Irene, Gueimonde Miguel, Margolles Abelardo, Suárez Ana
Primary Institution: University of Oviedo
Hypothesis
Can different Bifidobacterium strains induce specific T cell responses?
Conclusion
Different Bifidobacterium strains can stimulate immune cells to produce various cytokines, indicating their potential to polarize T cell responses.
Supporting Evidence
- Bifidobacterium strains can induce different cytokine profiles in immune cells.
- Some strains promote Th1 responses while others suggest Th17 profiles.
- DCs treated with Bifidobacterium can polarize T cells towards regulatory or effector functions.
Takeaway
Some good bacteria can help our body's defenses work better by teaching our immune cells how to react to germs.
Methodology
The study analyzed the immune activation properties of 21 Bifidobacterium strains using peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs).
Limitations
The study was conducted in vitro, which may not fully represent in vivo conditions.
Participant Demographics
Healthy adult volunteers provided PBMCs for the study.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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