Reduced Susceptibility to Artemisinin in a Traveler from Southeast Asia
Author Information
Author(s): Pradines Bruno, Bertaux Lionel, Pomares Christelle, Delaunay Pascal, Marty Pierre
Primary Institution: Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France
Hypothesis
Is there a reduced susceptibility to artemisinin derivatives in a patient returning from Southeast Asia?
Conclusion
The study found that the patient had reduced susceptibility to artemisinin derivatives and other anti-malarial drugs.
Supporting Evidence
- The patient showed decreased susceptibility to dihydroartemisinin and artesunate.
- Resistance was also noted against quinine, mefloquine, lumefantrine, pyronaridine, and piperaquine.
- The patient recovered after treatment with quinine and doxycycline.
Takeaway
A traveler from Southeast Asia had malaria that didn't respond well to common treatments, which is concerning.
Methodology
In vitro testing of drug susceptibility was performed using a standard 42-hour 3H-hypoxanthine uptake inhibition method.
Limitations
The study is based on a single case report, limiting the generalizability of the findings.
Participant Demographics
A 52-year-old female traveler.
Digital Object Identifier (DOI)
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