Fibronectin Matrix Assembly Suppresses Dispersal of Glioblastoma Cells
Author Information
Author(s): Sabari Joshua, Lax Daniel, Connors Daniel, Brotman Ian, Mindrebo Eric, Butler Christine, Entersz Ildiko, Jia Dongxuan, Foty Ramsey A.
Primary Institution: Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America
Hypothesis
Can fibronectin matrix assembly prevent the dispersal of glioblastoma cells from a tumor-like mass?
Conclusion
Restoring fibronectin matrix assembly in glioblastoma cells significantly reduces their dispersal velocity.
Supporting Evidence
- Aggregates from different glioblastoma cell lines spread at different rates.
- Restoring fibronectin matrix assembly significantly reduces the spreading velocity of glioblastoma cells.
- Blocking fibronectin matrix assembly rescues the spreading velocity of glioblastoma cells.
Takeaway
This study shows that a special protein called fibronectin helps keep brain cancer cells together, making it harder for them to spread out.
Methodology
The study used glioblastoma-derived cell lines to measure the dispersal velocity of cell aggregates on a solid substrate and assessed the effects of fibronectin matrix assembly.
Limitations
The study primarily used in vitro models, which may not fully replicate in vivo conditions.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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