Regeneration in a Degenerating Brain: Potential of Allopregnanolone as a Neuroregenerative Agent
2007
Allopregnanolone's Potential in Brain Regeneration
publication
Evidence: moderate
Author Information
Author(s): Ming Wang, Jun Irwin, Ronald W Liu, Lifei Chen, Shuhua Brinton, Roberta Diaz
Primary Institution: University of Southern California, School of Pharmacy
Hypothesis
Can allopregnanolone promote neurogenesis and modify Alzheimer's disease pathology?
Conclusion
Allopregnanolone may enhance neurogenesis and reduce Alzheimer's pathology in mouse models.
Supporting Evidence
- Allopregnanolone promotes proliferation of neural progenitor cells in vitro and in vivo.
- APα treatment reduced levels of Aβ and phospho-tau in the brains of treated mice.
- Neurogenic potential of APα varies with age and disease state in mouse models.
Takeaway
Allopregnanolone is a substance that might help the brain grow new cells and fight Alzheimer's disease.
Methodology
The study involved in vitro and in vivo analyses using neural progenitor cells and a triple transgenic mouse model of Alzheimer's disease.
Limitations
The study primarily focuses on animal models, which may not fully replicate human conditions.
Digital Object Identifier (DOI)
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