COX-2 and Survivin in Pterygium
Author Information
Author(s): Maxia Cristina, Perra Maria Teresa, Demurtas Paolo, Minerba Luigi, Murtas Daniela, Piras Franca, Cabrera Renè, Ribatti Domenico, Sirigu Paola
Primary Institution: University of Cagliari Medical School
Hypothesis
Is there a correlation between the expression of COX-2 and survivin in primary pterygium?
Conclusion
There is a significant correlation between COX-2 and survivin expression in primary pterygium, suggesting an anti-apoptotic mechanism in its origin.
Supporting Evidence
- 67.7% of primary pterygia samples were positive for COX-2 staining.
- 75.3% of primary pterygia specimens were positive for survivin expression.
- 78.6% of survivin-positive samples also showed COX-2 expression.
Takeaway
The study found that two proteins, COX-2 and survivin, are linked in eye growths called pterygia, which might help us understand how these growths form.
Methodology
Immunohistochemical evaluation of COX-2 and survivin in primary pterygium samples.
Participant Demographics
93 patients (36 males and 57 females), aged 18 to 77, mostly outdoor workers from mixed race backgrounds.
Statistical Information
P-Value
0.0002
Statistical Significance
p=0.0002
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