Evodia rutaecarpa and Its Alkaloids Reduce Inflammation from H1N1 Virus
Author Information
Author(s): Chiou Wen-Fei, Ko Han-Chieh, Wei Bai-Luh
Primary Institution: National Research Institute of Chinese Medicine
Hypothesis
Can Evodia rutaecarpa and its alkaloids inhibit chemokine production and cell migration induced by the H1N1 virus?
Conclusion
Evodia rutaecarpa and its active components effectively suppress H1N1-induced chemokine production and block cell migration.
Supporting Evidence
- Evodia rutaecarpa significantly inhibited RANTES secretion in H1N1-infected A549 cells.
- Evodiamine was the most potent alkaloid in reducing H1N1-induced chemokine production.
- Both RANTES and MCP-1 were shown to evoke cell migration in macrophages, which was suppressed by Evodia rutaecarpa.
Takeaway
This study found that a plant called Evodia rutaecarpa can help stop the body from making too many chemicals that cause inflammation when someone gets the flu.
Methodology
The study used A549 lung epithelial cells and HL-60-differentiated macrophages to assess the effects of Evodia rutaecarpa and its alkaloids on chemokine production and cell migration.
Limitations
The study did not explore the detailed mechanisms of how the alkaloids inhibit chemokine production and cell migration.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website