Impact of the Autophagy Machinery on Hepatitis C Virus Infection
2011
Impact of Autophagy on Hepatitis C Virus Infection
publication
Evidence: moderate
Author Information
Author(s): Dreux Marlène, Chisari Francis V.
Primary Institution: The Scripps Research Institute
Hypothesis
How do autophagy proteins influence the replication of hepatitis C virus (HCV)?
Conclusion
HCV utilizes autophagy proteins for its propagation and induces autophagic vesicle accumulation in infected cells.
Supporting Evidence
- HCV infection leads to the accumulation of autophagic vesicles in infected cells.
- Autophagy proteins are required for productive HCV infection.
- HCV can modulate the autophagy pathway to enhance its replication.
- Autophagy proteins can regulate the innate immune response against HCV.
Takeaway
This study shows that the hepatitis C virus uses the cell's recycling system, called autophagy, to help it reproduce.
Methodology
The review summarizes findings from various studies on the relationship between autophagy and HCV.
Limitations
The review does not provide new experimental data but synthesizes existing literature.
Digital Object Identifier (DOI)
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