Effects of DNA Vaccine on Lung Cancer Treatment
Author Information
Author(s): Lai Ming-Derg, Yen Meng-Chi, Lin Chiu-Mei, Tu Cheng-Fen, Wang Chun-Chin, Lin Pei-Shan, Yang Huei-Jiun, Lin Chi-Chen
Primary Institution: National Cheng Kung University, Taiwan
Hypothesis
How do different routes of administration and formulations of a xenogenic EGFR DNA vaccine affect its therapeutic efficacy in a lung cancer model?
Conclusion
Gene gun administration of a non-coating xenogenic EGFR DNA vaccine may be the preferred method for treating EGFR-positive lung tumors.
Supporting Evidence
- Gene gun administration of non-coating DNA vaccine generated the strongest T cell activity.
- CD8(+) T cells were essential for anti-tumor immunity.
- Non-coating DNA vaccine administered by gene gun delayed tumor growth significantly compared to control.
Takeaway
This study tested different ways to give a cancer vaccine to mice and found that one method worked best at fighting lung cancer.
Methodology
Mice were immunized with a xenogenic EGFR DNA vaccine using three different administration methods and the immune responses were measured.
Limitations
The study was conducted in a mouse model, which may not fully replicate human responses.
Participant Demographics
Inbred female C57BL/6 mice, aged 6–8 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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