How Müller Cells Affect Retinal Blood Vessels
Author Information
Author(s): Abukawa Hayato, Tomi Masatoshi, Kiyokawa Jumpei, Hori Satoko, Kondo Tetsu, Terasaki Tetsuya, Hosoya Ken-ichi
Primary Institution: University of Toyama
Hypothesis
Müller glial cell-derived factors modulate the expression of genes in retinal capillary endothelial cells.
Conclusion
Müller glial cell-derived factors can influence endothelial cell functions, promoting anti-angiogenic factors and suppressing pro-angiogenic factors.
Supporting Evidence
- Müller cell-derived factors increased alkaline phosphatase activity in endothelial cells.
- Microarray analysis showed modulation of several genes including PAI-1 and Id2.
- TGF-β1 treatment induced similar changes in gene expression as Müller cell factors.
Takeaway
Müller cells help control how blood vessels in the retina grow by sending signals that can either help or stop the growth.
Methodology
The study used conditionally immortalized rat retinal capillary endothelial and Müller cell lines to analyze gene expression changes after treatment with Müller cell-derived factors.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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