Severe propylthiouracil-induced hepatotoxicity in pregnancy managed successfully by liver transplantation: A case report
2011
Severe Liver Damage from Propylthiouracil in Pregnancy
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Sequeira Evan, Wanyonyi Sikolia, Dodia Raj
Primary Institution: Aga Khan University Hospital
Conclusion
The case highlights a rare complication of a commonly used drug during pregnancy, leading to severe liver damage and adverse neonatal outcomes.
Supporting Evidence
- Propylthiouracil-induced hepatotoxicity is rare but can lead to severe complications.
- The patient required a liver transplant due to stage IV liver failure.
- Neonatal outcomes were unfavorable, including growth restrictions and developmental delays.
Takeaway
A pregnant woman took a medicine that usually helps, but it made her liver very sick, and she needed a new liver to get better.
Methodology
The case was managed through liver transplantation and thyroidectomy after the patient developed fulminant hepatic failure.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
A 36-year-old black woman of African descent, gravida 2.
Digital Object Identifier (DOI)
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