High Plasma Cell Free DNA Concentration and Apoptotic DNA Fragmentation in Bacteremia
Author Information
Author(s): Huttunen Reetta, Kuparinen Taru, Jylhävä Juulia, Aittoniemi Janne, Vuento Risto, Huhtala Heini, Laine Janne, Syrjänen Jaana, Hurme Mikko
Primary Institution: Tampere University Hospital
Hypothesis
Is high plasma cell free DNA concentration associated with fatal outcomes in bacteremia?
Conclusion
Plasma cf-DNA concentration is a specific independent prognostic biomarker in bacteremia, with higher levels indicating a greater risk of death.
Supporting Evidence
- Patients with high cf-DNA levels had a significantly higher risk of death.
- cf-DNA levels were higher in nonsurvivors compared to survivors.
- High cf-DNA concentration was an independent risk factor for case fatality.
Takeaway
This study found that patients with high levels of cell-free DNA in their blood are more likely to die from bacteremia, which is a serious infection.
Methodology
The study measured plasma cf-DNA levels in 132 patients with bacteremia and analyzed the data using quantitative PCR and logistic regression.
Limitations
The study did not include a control group of critically ill patients without bacteremia, which limits the ability to compare cf-DNA levels.
Participant Demographics
Patients were adults aged 16 to 93, with a median age of 62, including 62 females and 70 males.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 0.69–0.94
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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