Low TBX4 Expression Linked to Poor Prognosis in Pancreatic Cancer
Author Information
Author(s): Zong Meijuan, Meng Meng, Li Liang
Primary Institution: Zibo Vocational Institute
Hypothesis
Does low expression of TBX4 correlate with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma?
Conclusion
A low level of TBX4 expression suggests a worse prognosis for patients with stage II pancreatic ductal adenocarcinoma.
Supporting Evidence
- 62.3% of stage II PDAC tumors expressed TBX4 at a high level.
- Patients with high TBX4 expression had significantly longer survival than those with low expression.
- Low TBX4 expression was identified as an independent prognostic factor for overall survival.
Takeaway
If a patient with pancreatic cancer has low levels of a protein called TBX4, they might not live as long as someone with higher levels of this protein.
Methodology
The study analyzed TBX4 expression in 77 stage II PDAC tumors using immunohistochemistry and assessed its correlation with clinicopathological characteristics and overall survival.
Limitations
The study is limited by its moderate sample size and retrospective design.
Participant Demographics
Median age of participants was 64 years, with a range from 38 to 84 years.
Statistical Information
P-Value
0.010
Statistical Significance
p=0.010
Digital Object Identifier (DOI)
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