Her2 and GEP100 Interaction in Lung Adenocarcinoma
Author Information
Author(s): Menju Toshi, Hashimoto Shigeru, Hashimoto Ari, Otsuka Yutaro, Handa Haruka, Ogawa Eiji, Todo Yoshinobu, Wada Hiromi, Date Hiroshi, Sabe Hisataka
Primary Institution: Kyoto University, Hokkaido University
Hypothesis
Does the interaction between overexpressed Her2 and GEP100 contribute to the invasive activities of lung adenocarcinoma cells?
Conclusion
The study found that overexpression of both Her2 and GEP100 in lung adenocarcinoma is correlated with increased invasive activities and node-metastasis.
Supporting Evidence
- Overexpression of Her2 is linked to poor prognosis in lung cancer.
- GEP100 expression is heterogeneous within lung adenocarcinoma specimens.
- Blocking the Her2-GEP100 pathway reduces cancer cell invasion.
- High levels of GEP100 expression correlate with node-metastasis in lung adenocarcinoma.
Takeaway
When certain cancer cells have too much Her2 and GEP100, they can grow and spread more easily in the body.
Methodology
The study involved analyzing lung adenocarcinoma specimens for Her2 and GEP100 expression and conducting Matrigel invasion assays on H522 cells.
Potential Biases
Potential bias in scoring immunohistochemical staining due to subjective interpretation by investigators.
Limitations
The study's findings may not be generalizable to all lung cancer types due to the focus on adenocarcinoma.
Participant Demographics
Patients with primary lung adenocarcinomas, aged 31-83, with a mix of current, former, and never smokers.
Statistical Information
P-Value
p=0.0197
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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