Genetic Variation in ATP5O and Its Impact on Muscle Function and Diabetes
Author Information
Author(s): Rönn Tina, Poulsen Pernille, Tuomi Tiinamaija, Isomaa Bo, Groop Leif, Vaag Allan, Ling Charlotte
Primary Institution: Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, CRC Malmö University Hospital, Lund University, Malmö, Sweden
Hypothesis
The study investigates the relationship between ATP5O expression in skeletal muscle and glucose metabolism, as well as the association of ATP5O SNPs with type 2 diabetes risk.
Conclusion
Genetic variation and age are associated with skeletal muscle ATP5O mRNA expression and glucose disposal rate, indicating that both genetic and non-genetic factors may contribute to reduced ATP5O expression in type 2 diabetes.
Supporting Evidence
- ATP5O mRNA expression was reduced in elderly compared to young twins.
- The mRNA level of ATP5O was positively related to insulin-stimulated glucose uptake.
- Two SNPs were associated with both ATP5O mRNA expression and glucose uptake in young twins.
Takeaway
This study found that younger people have higher levels of a specific gene related to energy use in muscles, which helps them use sugar better, while older people have lower levels of this gene.
Methodology
The study analyzed ATP5O mRNA expression in skeletal muscle from young and elderly non-diabetic twins and genotyped 11 SNPs from the ATP5O locus.
Limitations
The study could not detect any genetic association with type 2 diabetes, possibly due to low power.
Participant Demographics
Young twins (n=86) aged approximately 28 years and elderly twins (n=68) aged approximately 62 years, all non-diabetic.
Statistical Information
P-Value
p<0.0005
Statistical Significance
p<0.0005
Digital Object Identifier (DOI)
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