Sema6A's Role in Guiding Corticospinal Tract Axons
Author Information
Author(s): Rünker Annette E, Little Graham E, Suto Fumikazu, Fujisawa Hajime, Mitchell Kevin J
Primary Institution: Trinity College Dublin
Hypothesis
How do transmembrane semaphorins and their receptors influence the guidance of corticospinal tract axons?
Conclusion
Sema6A is a key factor in guiding corticospinal tract axons at various choice points, particularly at the mid-hindbrain boundary and in the hindbrain.
Supporting Evidence
- Sema6A mutants showed significant defects in corticospinal tract guidance.
- Defects were observed at the mid-hindbrain boundary and in the hindbrain.
- Sema6A is expressed by oligodendrocytes, suggesting a role in CST regeneration.
Takeaway
Sema6A helps direct brain signals down the right paths in the body, and when it doesn't work right, it can cause problems with movement.
Methodology
The study involved genetic analysis of Sema6A mutants and tracing corticospinal tract axons using DiI dye.
Limitations
The study primarily focused on specific genetic mutants, which may not represent all aspects of corticospinal tract guidance.
Digital Object Identifier (DOI)
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