How a Non-Pathogenic Virus Protects Cats from Feline Immunodeficiency Virus
Author Information
Author(s): Padhi Abinash, Ross Howard, Terwee Julie, VandeWoude Sue, Poss Mary
Primary Institution: The Pennsylvania State University
Hypothesis
Does a preexisting apathogenic lentivirus infection protect against disease caused by a virulent lentivirus?
Conclusion
The study found that prior infection with a non-pathogenic virus alters the population dynamics of a pathogenic virus, leading to disease attenuation.
Supporting Evidence
- Prior infection with a non-pathogenic virus prevented CD4 decline in cats.
- FIVC populations in dual infected cats had a significantly smaller effective population size.
- Genetic diversity indices indicated that both single and dual infection environments were expanding or under purifying selection.
Takeaway
Cats that get a harmless virus first can fight off a more dangerous virus better, like having a shield against it.
Methodology
The study used population genetic approaches to analyze the viral genetic structure in single and dual infected cats.
Potential Biases
Potential bias due to the limited sample size and specific conditions of the study.
Limitations
The study did not detect significant differences in blood counts of naïve and PLV-infected cats, which may limit the understanding of immune responses.
Participant Demographics
Cats infected with either a non-pathogenic or pathogenic strain of FIV.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website