Genetic Variation in p22-phox and Heart Health
Author Information
Author(s): Roberto Schreiber, Maria C Ferreira-Sae, Juliana A Ronchi, José A Pio-Magalhães, José A Cipolli, José R Matos-Souza, José G Mill, Aníbal E Vercesi, José E Krieger, Kleber G Franchini, Alexandre C Pereira, Wilson Nadruz Junior
Primary Institution: University of Campinas
Hypothesis
Is the C242T polymorphism of the p22-phox gene associated with left ventricular structure in Brazilian hypertensive patients?
Conclusion
The T allele of the p22-phox C242T polymorphism is linked to higher left ventricular mass and increased NADPH-oxidase activity in Brazilian hypertensive patients.
Supporting Evidence
- Subjects with the T allele had higher left ventricular mass compared to those with the CC genotype.
- Increased NADPH-oxidase activity was found in peripheral mononuclear cells from T allele carriers.
- The study included a large sample size of 561 hypertensive patients.
Takeaway
Some people have a gene that makes their heart bigger when they have high blood pressure, which can be bad for their health.
Methodology
The study evaluated 561 hypertensive patients through clinical history, physical examination, and genetic testing for the p22-phox C242T polymorphism.
Potential Biases
Potential confounding factors like duration of hypertension and diabetes control were not included in the analysis.
Limitations
Some subjects were on medications, which may have influenced the results.
Participant Demographics
561 unrelated hypertensive subjects from two centers in Brazil, with 441 from Campinas and 120 from Vitória.
Statistical Information
P-Value
p = 0.009 (Campinas), p = 0.023 (Vitória)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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