Diabetes Impairs Bone Marrow Stem Cells
Author Information
Author(s): Li Tao-Sheng, Ikeda Satoshi, Kubo Masayuki, Ohshima Mako, Kurazumi Hiroshi, Takemoto Yoshihiro, Ueda Kazuhiro, Hamano Kimikazu
Primary Institution: Department of Stem Cell Biology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
Hypothesis
The study investigates the mechanisms responsible for diabetes-related functional impairment of bone marrow stem cells.
Conclusion
Diabetes leads to an increase in inflammatory factors and changes in extracellular matrix and adhesion molecules in bone marrow stem cells, contributing to their functional impairment.
Supporting Evidence
- Diabetic mice had significantly fewer c-kit+ stem cells compared to healthy controls.
- c-kit+ stem cells from diabetic mice showed lower potency of endothelial differentiation.
- Diabetes increased the expression of inflammatory-related factors in c-kit+ bone marrow stem cells.
Takeaway
Diabetes makes special cells in the bone marrow not work as well, which can cause problems in healing and repairing the body.
Methodology
Bone marrow cells were collected from diabetic and healthy mice, and c-kit+ stem cells were purified for analysis of inflammatory factors and cell adhesion molecules.
Limitations
The study did not identify the critical factors inducing functional impairment and only screened three pathways.
Participant Demographics
12-week-old male C57BLKS/J mice, including diabetic and healthy control groups.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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