Diffusion Tensor Imaging of Post Mortem Multiple Sclerosis Brain
Author Information
Author(s): Klaus Schmierer, Claudia A.M. Wheeler-Kingshott, Phil A. Boulby, Francesco Scaravilli, Daniel R. Altmann, Gareth J. Barker, Paul S. Tofts, David H. Miller
Primary Institution: Institute of Neurology, University College London
Hypothesis
This study investigates the association between histological indices of myelin content, axonal count, and gliosis with diffusion tensor imaging measures in post mortem MS brain.
Conclusion
The study suggests that mean diffusivity (MD) and fractional anisotropy (FA) are significantly affected by myelin content and, to a lesser degree, axonal count in post mortem MS brain.
Supporting Evidence
- Mean diffusivity (MD) was significantly higher in white matter lesions compared to normal-appearing white matter.
- Fractional anisotropy (FA) was significantly lower in white matter lesions compared to normal-appearing white matter.
- Strong correlations were found between myelin content and both FA and MD.
Takeaway
Researchers looked at brain samples from people with multiple sclerosis to see how well certain imaging techniques can show damage to the brain's protective covering and nerve fibers.
Methodology
The study used diffusion tensor imaging on post mortem brain samples from 16 MS patients to analyze the relationship between imaging measures and histological features.
Limitations
The study is limited to chronic post mortem MS brain and may not reflect early inflammatory changes or in vivo conditions.
Participant Demographics
15 women and 1 man, mean age 59 years, mean disease duration 25 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website