Donepezil Prevents Cardiac Rupture in Mice After Heart Attack
Author Information
Author(s): Arikawa Mikihiko, Kakinuma Yoshihiko, Handa Takemi, Yamasaki Fumiyasu, Sato Takayuki
Primary Institution: Kochi Medical School, Nankoku, Kochi, Japan
Hypothesis
Donepezil attenuates an acute inflammatory tissue injury following myocardial infarction.
Conclusion
Donepezil inhibits MMP-9-related acute inflammatory tissue injury in the infarcted myocardium, thereby reducing the risk of cardiac rupture during the acute phase of myocardial infarction.
Supporting Evidence
- Donepezil significantly reduced MMP-9 secretion in macrophages.
- The incidence of cardiac rupture was significantly lower in donepezil-treated mice compared to untreated mice.
- Donepezil treatment did not affect heart rate and blood pressure in normal and infarcted mice.
Takeaway
Donepezil, a drug usually used for Alzheimer's, helps protect the heart from damage after a heart attack by reducing inflammation.
Methodology
Mice were treated with donepezil after inducing myocardial infarction, and various physiological and histological analyses were performed.
Limitations
The study was conducted in mice, and the effects in humans may differ.
Participant Demographics
Male C57BL/6 mice aged between 9 and 11 weeks.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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