Complete Genome Analysis of Stenotrophomonas maltophilia
Author Information
Author(s): Lisa C Crossman, Virginia C Gould, J Maxwell Dow, Georgios S Vernikos, Aki Okazaki, Mohammed Sebaihia, David Saunders, Claire Arrowsmith, Tim Carver, Nicholas Peters, Ellen Adlem, Arnaud Kerhornou, Angela Lord, Lee Murphy, Katharine Seeger, Robert Squares, Simon Rutter, Michael A Quail, Mari-Adele Rajandream, David Harris, Carol Churcher, Stephen D Bentley, Julian Parkhill, Nicholas R Thomson, Matthew B Avison
Primary Institution: The Wellcome Trust Sanger Institute
Hypothesis
The complete genome sequence of Stenotrophomonas maltophilia reveals its potential as a reservoir of antibiotic resistance determinants.
Conclusion
The study indicates that Stenotrophomonas maltophilia can act as a reservoir of antimicrobial drug resistance determinants in clinical environments.
Supporting Evidence
- The genome of S. maltophilia K279a is 4,851,126 bp and has a high G+C content.
- S. maltophilia possesses multiple genes conferring resistance to various antimicrobial drugs.
- Functional genomic analysis confirms a role in drug resistance for several novel RND efflux pumps.
- The organism has mobile regions of DNA that may contribute to its resistance.
- S. maltophilia can provide antibiotic resistance protection for nearby sensitive strains.
Takeaway
Scientists studied a germ called Stenotrophomonas maltophilia and found it has many ways to resist antibiotics, making it hard to treat infections.
Methodology
The genome was sequenced and analyzed for drug resistance genes and mobile genetic elements.
Digital Object Identifier (DOI)
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