Ahmedabad Tolerance Induction Protocol and Chronic Renal Allograft Dysfunction
Author Information
Author(s): Rashmi D Patel, Aruna V Vanikar, Feroz A Aziz, Pankaj R Shah, Hargovind L Trivedi
Primary Institution: G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences, Ahmedabad, India
Hypothesis
The study aims to evaluate the effect of the Ahmedabad Tolerance Induction Protocol (ATIP) on chronic renal allograft dysfunction (CRAD) in living-related renal allograft recipients.
Conclusion
Transplantation using ATIP yields a lesser incidence of chronic immune injuries compared to controls, but a higher incidence of chronic calcineurin inhibitor toxicity.
Supporting Evidence
- Chronic changes were noted in 10.98% of ATIP biopsies compared to 17.5% in controls.
- Hypertension was observed in 66.4% of ATIP patients versus 41.9% in controls.
- Proteinuria was recorded in 43% of ATIP patients compared to 80.6% in controls.
- Chronic changes attributed to calcineurin inhibitor toxicity were higher in the ATIP group at 71.9%.
Takeaway
This study shows that a special treatment method for kidney transplants helps reduce some long-term problems but can cause other issues.
Methodology
This was a retrospective study analyzing renal allograft biopsies performed at the center over four years.
Limitations
The two groups in this study are unequal in size since most patients opt for transplantation with ATIP due to its benefits.
Participant Demographics
The ATIP group included 63 males and 14 females with a mean age of 34 years, while the control group had 10 males and 5 females with a mean age of 34 years.
Digital Object Identifier (DOI)
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