Permanent Relief from Fibromyalgia-like Pain with Antidepressants
Author Information
Author(s): Nishiyori Michiko, Uchida Hitoshi, Nagai Jun, Araki Kohei, Mukae Takehiro, Kishioka Shiroh, Ueda Hiroshi
Primary Institution: Nagasaki University Graduate School of Biomedical Sciences
Hypothesis
Can repeated intrathecal administration of antidepressants provide lasting relief from fibromyalgia-like pain induced by intermittent cold stress in mice?
Conclusion
The study found that repeated intrathecal administration of antidepressants can permanently cure fibromyalgia-like pain in mice.
Supporting Evidence
- Repeated daily antidepressant treatments reversed the reduction in thermal pain threshold.
- Relief from mechanical allodynia was observed even after treatment cessation.
- Intravenous administration of antidepressants did not provide relief.
Takeaway
Giving mice antidepressants directly into their spine can help them feel better from pain that doesn't go away easily, like what some people with fibromyalgia experience.
Methodology
Mice were subjected to intermittent cold stress and treated with various antidepressants via intrathecal injection to assess pain relief.
Limitations
The study was conducted on mice, which may not fully replicate human fibromyalgia conditions.
Participant Demographics
Male C57BL/6J mice, weighing 18-22 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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