Role of Collagen IV in Rheumatic Fever
Author Information
Author(s): Dinkla Katrin, Talay Susanne R., Mörgelin Matthias, Graham Rikki M. A., Rohde Manfred, Nitsche-Schmitz D. Patric, Chhatwal Gursharan S.
Primary Institution: Helmholtz Centre for Infection Research
Hypothesis
The interaction between streptococcal M-proteins and collagen IV is crucial in the pathogenesis of acute rheumatic fever.
Conclusion
The study identifies the CB3-region of collagen IV as a significant binding site for streptococcal M-proteins, which may contribute to autoimmune responses in rheumatic fever.
Supporting Evidence
- M3-protein binds to two prominent sites on collagen IV.
- Immunization with M3-protein induces auto-antibodies against collagen IV.
- Elevated titers of anti-CB3 antibodies were found in patients with ARF.
Takeaway
This study shows that a part of collagen can stick to a bacteria's protein, which might make the body attack itself and cause sickness.
Methodology
The study used electron microscopy, radioactive binding assays, and surface plasmon resonance to analyze the interactions between M3-protein and collagen IV.
Participant Demographics
Sera from patients with acute rheumatic fever and healthy individuals were analyzed.
Statistical Information
P-Value
0.0085
Statistical Significance
p=0.0085
Digital Object Identifier (DOI)
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