Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey

2011

Omeprazole Improves Quality of Life in Heart Patients

Sample size: 48 publication 10 minutes Evidence: moderate

Author Information

Author(s): Budzyński Jacek, Pulkowski Grzegorz, Suppan Karol, Fabisiak Jacek, Majer Marcin, Kłopocka Maria, Galus-Pulkowska Beata, Wasielewski Marcin

Primary Institution: Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland

Hypothesis

Does omeprazole treatment improve health-related quality of life in patients with coronary artery disease and recurrent angina-like chest pain?

Conclusion

A double dose of omeprazole improved the general health-related quality of life in patients with coronary artery disease without severe gastrointestinal symptoms more effectively than the placebo.

Supporting Evidence

Patients treated with omeprazole had significantly greater SF-36 scores compared to those on placebo.
Omeprazole improved physical functioning, bodily pain, and general health perception.
The study showed a 72% improvement in limitations due to physical health problems after omeprazole treatment.

Takeaway

Taking omeprazole can help people with heart problems feel better overall, not just in their stomachs.

Methodology

A double-blind, placebo-controlled, cross-over study design where 48 patients were randomized to take omeprazole or placebo for two weeks, followed by a crossover.