Repeatability of Myocardial Blood Flow Calculation in PET Imaging
Author Information
Author(s): Knešaurek Karin, Machac Josef, Zhang Zhuangyu
Primary Institution: The Mount Sinai Medical Centre, New York, NY, USA
Hypothesis
The research aims to prove high repeatability for global and regional myocardial blood flow (MBF) and coronary flow reserve (CFR) values using 82Rb PET imaging.
Conclusion
The study demonstrates that software calculation of MBF and CFR with 82Rb myocardial PET imaging is highly repeatable for global values and has good repeatability for regional values.
Supporting Evidence
- Global rest and stress MBF showed very good repeatability.
- Global CFR was highly reproducible.
- Repeatability coefficients for global rest MBF were 0.033 (5.2%) and stress MBF 0.062 (4.5%) mL/min/g.
Takeaway
This study shows that measuring blood flow in the heart using a special imaging technique is very reliable, which means doctors can trust the results.
Methodology
12 normal volunteers were imaged at rest and during pharmacological stress using a GE Advance PET system, and MBF was calculated with a 2-compartmental model.
Limitations
The study may have limitations related to the small sample size and the specific population of healthy volunteers.
Participant Demographics
12 normal volunteers, mean age 35 ± 9.5 years.
Digital Object Identifier (DOI)
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