High Angiopoietin-1 Levels Predict Poor Survival in Myelodysplastic Syndromes
Author Information
Author(s): Cheng C-L, Hou H-A, Jhuang J-Y, Lin C-W, Chen C-Y, Tang J-L, Chou W-C, Tseng M-H, Yao M, Huang S-Y, Ko B-S, Hsu S-C, Wu S-J, Tsay W, Chen Y-C, Tien H-F
Primary Institution: National Taiwan University Hospital
Hypothesis
Does high expression of angiopoietin-1 in bone marrow correlate with poor prognosis in patients with myelodysplastic syndromes?
Conclusion
Higher expression of angiopoietin-1 in bone marrow is an independent poor prognostic factor for overall survival in patients with myelodysplastic syndromes.
Supporting Evidence
- Patients with higher Ang-1 expression had a higher frequency of disease transformation to acute leukaemia (31.5% vs 18.6%).
- Patients with higher Ang-1 expression had shorter overall survival (median 20.8 months vs 63.3 months).
- Higher Ang-1 expression was identified as an independent unfavourable prognostic factor for overall survival.
Takeaway
If a patient has a lot of a certain protein called angiopoietin-1 in their bone marrow, they might not live as long because it can mean their disease is worse.
Methodology
The study analyzed the expression of angiogenic factors in bone marrow samples from 208 patients with newly diagnosed primary myelodysplastic syndromes using real-time quantitative polymerase chain reaction.
Limitations
Not all patients had bone marrow biopsies, limiting the ability to measure Ang-1 protein expression in every case.
Participant Demographics
143 males and 65 females with a median age of 65 years.
Statistical Information
P-Value
P=0.005
Confidence Interval
95% CI, 1.204–2.892
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website