PDE4 as a target in preterm labour
2007
Targeting PDE4 to Prevent Preterm Labor
publication
Evidence: moderate
Author Information
Author(s): Céline Méhats, Thomas Schmitz, Stéphanie Oger, Roxane Hervé, Dominique Cabrol, Marie-Josèphe Leroy
Primary Institution: Institut National de la Santé et de la Recherche Médicale, INSERM U767
Hypothesis
Can PDE4 inhibitors prevent inflammation-induced preterm delivery?
Conclusion
PDE4 inhibitors may offer a new strategy to prevent preterm delivery caused by inflammation.
Supporting Evidence
- PDE4B2 expression increases in the near-term myometrium compared to nonpregnant state.
- PDE4 inhibitors can completely relax myometrial strips in both nonpregnant and pregnant states.
- PDE4 inhibition prevents inflammation-induced preterm delivery in mice.
Takeaway
This study suggests that certain drugs can help stop early births caused by inflammation in pregnant women.
Methodology
The study involved examining PDE4 expression in human myometrium and testing the effects of PDE4 inhibitors on myometrial contractility.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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