Oxytocin and GI Issues in Diabetics
Author Information
Author(s): Borg Julia, Melander Olle, Johansson Linda, Uvnäs-Moberg Kerstin, Rehfeld Jens F, Ohlsson Bodil
Primary Institution: Malmö University Hospital, Lund University
Hypothesis
Do hormone levels differ in diabetics with normal and delayed gastric emptying?
Conclusion
The study found that oxytocin secretion is reduced in patients with delayed gastric emptying, while CCK and gastrin levels are increased in patients with oesophageal dysmotility and autonomic neuropathy.
Supporting Evidence
- Patients with normal gastric emptying had increased oxytocin levels after a meal.
- Delayed gastric emptying showed no increase in oxytocin secretion.
- CCK and gastrin levels increased post-meal in all patients, regardless of gastric emptying status.
- Patients with oesophageal dysmotility had higher basal CCK levels.
- Gastrin levels were higher in patients with autonomic neuropathy.
Takeaway
This study looked at how certain hormones behave in diabetics with stomach problems. It found that some hormones don't work as well when the stomach is slow to empty.
Methodology
Nineteen diabetic patients underwent gastric emptying scintigraphy, oesophageal manometry, and blood tests after a fat-rich meal.
Potential Biases
Potential bias due to the exclusion of patients with regular use of medications affecting GI motility.
Limitations
The study had a small sample size and excluded patients with certain conditions, which may limit the generalizability of the findings.
Participant Demographics
19 patients, 10 women, 17 with type 1 diabetes and 2 with type 2 diabetes.
Statistical Information
P-Value
p = 0.015 for oxytocin in normal gastric emptying
Confidence Interval
[116.0–362.5] for delayed gastric emptying
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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