The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation
2008
EPA Protects Muscle Cells from TNF-Alpha Damage
publication
Evidence: moderate
Author Information
Author(s): Peter Magee, Stephen Pearson, Jeremy Allen
Primary Institution: University of Salford
Hypothesis
EPA may have a protective effect against skeletal muscle damage induced by pro-inflammatory TNF-α.
Conclusion
EPA has a protective action against the damaging effects of TNF-α on C2C12 myogenesis.
Supporting Evidence
- EPA completely inhibited the deleterious effects of TNF-α on myogenesis.
- EPA significantly increased myogenic fusion and myotube diameter back to control levels.
- EPA reduced spontaneous apoptosis and necrosis of differentiating myotubes.
Takeaway
EPA is like a superhero for muscle cells, helping them stay strong and healthy even when a bad guy called TNF-α tries to hurt them.
Methodology
The study used murine C2C12 myoblasts to evaluate the effects of EPA and TNF-α on myogenic differentiation and apoptosis.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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