A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas
2011
One-Pot Synthesis of Isoindolin-1-ones
publication
Evidence: high
Author Information
Author(s): Smith Keith, El-Hiti Gamal A, Hegazy Amany S, Kariuki Benson
Primary Institution: School of Chemistry, Cardiff University
Hypothesis
Can a simple one-pot synthesis method be developed for substituted isoindolin-1-ones?
Conclusion
The study presents a novel and efficient one-step method for synthesizing isoindolin-1-ones with high yields.
Supporting Evidence
- The method allows for easy addition of various substituents to the benzene ring.
- High yields of products were achieved with a variety of electrophiles.
- Isolation of pure products is straightforward, involving simple trituration.
Takeaway
Scientists found a new way to make a special type of chemical called isoindolin-1-ones in just one step, which is easier and faster than before.
Methodology
Lithiation of N'-benzyl-N,N-dimethylureas with t-BuLi in THF followed by reaction with various electrophiles.
Limitations
The method may produce two diastereoisomers in some cases, complicating product isolation.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website