Entrapment of water by subunit c of ATP synthase
2007

How an Ancient Protein Encapsulates Water

publication Evidence: moderate

Author Information

Author(s): McGeoch Julie E.M, McGeoch Malcolm W

Primary Institution: Harvard University

Hypothesis

Subunit c of ATP synthase can encapsulate water, potentially aiding early complex chemistry.

Conclusion

The study shows that subunit c of ATP synthase can change its structure to encapsulate water, which may have been crucial for early biochemical processes.

Supporting Evidence

  • Subunit c can change its hydrogen bonding structure to encapsulate water.
  • The protein can retain water over a temperature rise from 123 to 223 K.
  • The encapsulated water forms highly ordered hexagonal crystals.

Takeaway

A special protein can wrap around water like a balloon, which might have helped life start a long time ago.

Methodology

The study involved mixing purified subunit c with water and observing the formation of vesicles and tubes using microscopy techniques.

Limitations

The study primarily focuses on a specific protein and its interactions with water, which may not represent all proteins or conditions.

Digital Object Identifier (DOI)

10.1098/rsif.2007.1146

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