RCAS1 Expression in Laryngeal and Pharyngeal Cancer and Its Role in Cancer Relapse
Author Information
Author(s): Dutsch-Wicherek Magdalena, Tomaszewska Romana, Lazar Agata, Wicherek Lukasz, Skladzien Jacek
Primary Institution: Jagiellonian University
Hypothesis
The study aims to establish the level of RCAS1 expression in laryngeal and pharyngeal cancer and its healthy stroma in relation to cancer relapse.
Conclusion
Higher levels of RCAS1 expression in clear surgical margins are associated with an increased risk of cancer relapse.
Supporting Evidence
- RCAS1 was found in all cancer samples and almost all clear surgical margins.
- Higher RCAS1 levels were linked to higher cancer grades and lymph node metastases.
- Patients with higher RCAS1 in clear margins had a greater chance of cancer recurrence.
Takeaway
This study found that a protein called RCAS1 is more common in cancer tissues and its presence in the surrounding healthy tissue can mean the cancer might come back.
Methodology
The study analyzed 122 tissue samples using immunohistochemistry and Western blot techniques to assess RCAS1 expression.
Potential Biases
Potential selection bias in patient sampling and the observational nature of the study.
Limitations
The study only followed patients for 4 years, which may not capture long-term outcomes.
Participant Demographics
{"age":"55.3 (42–74)","sex_distribution":{"men":41,"women":10},"lymph_node_metastasis":{"negative":24,"positive":27}}
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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