IGF-1 and Bone: New Discoveries From Mouse Models
2010
IGF-1 and Bone: New Discoveries From Mouse Models
publication
Evidence: moderate
Author Information
Author(s): Shoshana Yakar, Hayden-William Courtland, David Clemmons
Primary Institution: Mount Sinai School of Medicine
Hypothesis
What are the roles of IGF-1 in skeletal growth and development as observed in mouse models?
Conclusion
The study highlights the critical roles of IGF-1 in skeletal growth and development, emphasizing its importance in both endocrine and tissue-specific contexts.
Supporting Evidence
- IGF-1 is essential for early growth and skeletal development.
- Mouse models show that deficiencies in IGF-1 lead to significant growth retardation.
- Alterations in IGF-1 signaling can affect bone density and size.
Takeaway
IGF-1 is like a growth helper for bones, and scientists learned a lot about how it works by studying mice.
Methodology
The review discusses findings from various mouse models to understand the role of IGF-1 in bone physiology.
Limitations
The review does not provide new experimental data but synthesizes existing findings from multiple studies.
Digital Object Identifier (DOI)
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