Monocyte Activation and Cytokine Levels in Peripheral Arteriosclerosis
Author Information
Author(s): Corrêa Camila R, Dias-Melicio Luciane A, Calvi Sueli A, Lastória Sidney, Soares Angela MVC
Primary Institution: UNESP - Univ Estadual Paulista, Faculdade de Medicina - Campus Botucatu
Hypothesis
The study aims to evaluate plasma levels of cytokines and monocyte activation in patients with peripheral arteriosclerosis obliterans.
Conclusion
Patients with peripheral arteriosclerosis obliterans showed higher plasma cytokine levels but lower monocyte responses in vitro compared to control subjects.
Supporting Evidence
- Plasma levels of all cytokines were significantly higher in patients compared to control subjects.
- Monocytes from patients showed lower hydrogen peroxide production and fungicidal activity than those from control subjects.
- The study included ten male patients over 60 years old with moderate intermittent claudication.
Takeaway
The study found that patients with a certain blood flow problem have high levels of certain proteins in their blood, but their immune cells don't work as well as those of healthy people.
Methodology
The study measured cytokine levels in plasma and assessed monocyte activation through hydrogen peroxide production and fungicidal activity against Candida albicans.
Potential Biases
Potential bias due to the small sample size and the exclusion of subjects with chronic diseases.
Limitations
The study was limited to male subjects over 60 years old and may not be generalizable to other populations.
Participant Demographics
Ten male patients over 60 years old with moderate intermittent claudication.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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