Synthesis of [2.2]metacyclophanes using LiNK chemistry
Author Information
Author(s): Blangetti Marco, Fleming Patricia, O'Shea Donal F, Snieckus Victor
Primary Institution: University College Dublin
Hypothesis
Can a new two-step approach using LiNK metalation conditions effectively synthesize [2.2]metacyclophanes from substituted m-xylenes?
Conclusion
The study presents a new two-step method for synthesizing [2.2]metacyclophanes that is simpler and more efficient than previous methods.
Supporting Evidence
- The method allows for the synthesis of potentially useful planar chiral derivatives.
- The approach compares favorably with previously reported methods.
- The study demonstrated good to excellent yields for the targeted homo-dimer products.
Takeaway
Scientists found a new way to make special chemical structures called [2.2]metacyclophanes using a simpler method that works better than older ones.
Methodology
The study used a two-step process involving selective benzylic metalation and oxidative C–C bond formation under LiNK metalation conditions.
Limitations
The study does not address the scalability of the method or potential side reactions in complex substrates.
Digital Object Identifier (DOI)
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