Efficiency of complex production in changing environment
2009
Efficiency of Protein Complex Production in Yeast
Sample size: 6000
publication
Evidence: high
Author Information
Author(s): Carmi Shai, Levanon Erez Y, Eisenberg Eli
Primary Institution: Bar-Ilan University
Hypothesis
How do cells regulate protein levels to optimize complex formation?
Conclusion
The study indicates that yeast cells have intricate regulation mechanisms to optimize protein complex formation.
Supporting Evidence
- Proteins in the same complex tend to have similar levels that change similarly under different growth conditions.
- Abundant proteins show a larger decrease in their levels when grown in minimal media.
- Noise in protein levels is significantly lower in large complexes and for the least abundant protein in each complex.
Takeaway
Cells work hard to make sure that proteins that work together are produced in similar amounts, especially when conditions change.
Methodology
The study integrated data on yeast protein complexes and their concentrations under different growth conditions, using a mathematical model to analyze complex synthesis efficiency.
Participant Demographics
Yeast proteins
Statistical Information
P-Value
p<10-15
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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